BNIP3L

Across TCGA pan-cancer cohorts, BNIP3L RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of BNIP3L’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where BNIP3L RNA is more highly expressed in tumor relative to normal tissue. In most cancer types BNIP3L is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

KIRC, KICH, and HNSC are the cancer types where BNIP3L tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in BNIP3L RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	III,IV	+1.270	<.001	12	view →
KICH	Female	II,III,IV	−2.850	<.001	8	view →
HNSC	All	All	+0.549	<.001	8	view →
THCA	All	All	−0.320	<.001	7	view →
KIRP	All	II,III,IV	+0.570	.003	5	view →
BRCA	All	All	−0.541	<.001	4	view →
LUAD	All	III,IV	−0.519	.008	4	view →
CHOL	All	All	+1.376	<.001	3	view →
PRAD	All	All	−0.570	<.001	2	view →
UCEC	All	All	−0.493	.029	2	view →
READ	Female	All	−1.070	.017	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

BNIP3L–KIRC

Open the KIRC breakdown →