BNIP3L

Across TCGA pan-cancer cohorts, BNIP3L RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated BNIP3L data layer compared with 5 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in kidney chromophobe (KICH), where higher BNIP3L RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated BNIP3L expression acts as an unfavorable survival marker, although some lineages such as KIRC and PRAD show a favorable association.

KICH, MESO, and KIRC are the cancer types where BNIP3L RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KICH	DFS	Median	II,III,IV	0.679	1.000	.001	79	view →
MESO	DFS	Quartile	III,IV	0.226	0.560	<.001	76	view →
KIRC	OS	Median	All	0.706	0.549	<.001	72	view →
STAD	DFS	Quartile	All	0.191	0.506	.002	69	view →
BLCA	DFS	Tertile	All	0.223	0.613	.003	35	view →
LIHC	DFS	Tertile	All	0.448	0.605	.002	31	view →
THCA	OS	Quartile	II,III,IV	0.939	1.000	.010	23	view →
ACC	OS	Tertile	All	0.797	0.955	.013	22	view →
PRAD	DFS	Tertile	All	0.907	0.679	<.001	18	view →
LUAD	DFS	Quartile	III,IV	0.891	0.494	.004	16	view →
DLBC	DFS	Quartile	IV	1.000	0.271	.038	6	view →
PAAD	OS	Quartile	II,III,IV	0.572	0.342	.031	4	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

BNIP3L–KICH (DFS)

Open the KICH breakdown →