Across TCGA patient cohorts, BLOC1S4 protein abundance is significantly associated with the RNA expression of many other genes, with 8,598 significant associations in total. GBM shows the largest number of these associations.

The most reproducible BLOC1S4-associated genes across cancer lineages are KMO, DAB2, and NFATC2. Each is linked with BLOC1S4 in more than 3 cancer types. Because this analysis shows association rather than direction, both BLOC1S4-to-partner and partner-to-BLOC1S4 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BLOC1S4→partner) and Y-score (partner→BLOC1S4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	KMO →	+0.941	+0.271	<.001	.001	3	4
GBM	DAB2 →	+0.705	+0.244	<.001	<.001	3	4
HNSC	NFATC2 →	+0.649	+0.191	.001	.001	3	3
HNSC	MAP4K1 →	+0.843	+0.203	<.001	<.001	3	3
HNSC	MAN1C1 →	+0.631	+0.211	.003	.002	3	3
HNSC	ARHGAP9 →	+0.687	+0.203	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,598 associations by consensus.

Exploration

BLOC1S4 survival (RNA) · tumor vs normal (RNA) · all BLOC1S4 data types