Across TCGA pan-cancer cohorts, BLOC1S4 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of BLOC1S4’s most consistent transcriptional readouts.
The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where BLOC1S4 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types BLOC1S4 is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.
KIRC, HNSC, and LIHC are the cancer types where BLOC1S4 tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in BLOC1S4 RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.