Across TCGA pan-cancer cohorts, BLOC1S4 RNA is linked to patient survival in 28 of 34 cancer types, making it the most broadly survival-associated BLOC1S4 data layer compared with 6 for mass-spec protein.
The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher BLOC1S4 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated BLOC1S4 expression acts as an unfavorable survival marker, although some lineages such as UCEC and SCLC show a favorable association.
KIRP, LIHC, and LUAD are the cancer types where BLOC1S4 RNA most reproducibly stratifies survival.
RNA survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.