B2M

Across TCGA cell cohorts, B2M protein abundance is significantly associated with the RNA expression of many other genes, with 5,193 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible B2M-associated genes across cancer lineages are PSMB8, HLA-C, and HLA-A. Each is linked with B2M in more than 15 cancer types. Because this analysis shows association rather than direction, both B2M-to-partner and partner-to-B2M results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, B2M versus PSMB8 in SOFT_TISSUE, with a Pearson correlation of 0.81.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (B2M→partner) and Y-score (partner→B2M) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	PSMB8 →	+5.160	+2.259	<.001	<.001	3	16
LIVER	HLA-C →	+4.387	+3.965	.001	<.001	3	15
BREAST	HLA-A →	+3.910	+2.498	<.001	<.001	3	15
BREAST	PSMB9 →	+3.530	+2.776	<.001	<.001	3	15
BREAST	HLA-B →	+4.248	+2.462	<.001	<.001	3	14
LIVER	TAP1 →	+4.367	+3.567	.003	.002	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,193 associations by consensus.

B2M vs PSMB8 — SOFT_TISSUE

Explore this scatter interactively →