B2M

Across TCGA pan-cancer cohorts, B2M RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of B2M’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where B2M RNA is more highly expressed in tumor relative to normal tissue. In most cancer types B2M is over-expressed in tumor, although a few such as LUAD and LUSC show the opposite, repressed pattern.

KIRC, HNSC, and LUAD are the cancer types where B2M tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in B2M RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	All	+1.570	<.001	12	view →
HNSC	Female	III,IV	+1.552	<.001	11	view →
LUAD	Female	III,IV	−1.495	<.001	9	view →
LUSC	Male	III,IV	−2.284	<.001	8	view →
COAD	Female	All	−1.003	<.001	7	view →
KIRP	Male	All	+0.711	.001	6	view →
UCEC	All	IV	−1.969	.011	4	view →
ESCA	All	All	+1.561	.001	4	view →
THCA	Male	II,III,IV	+0.974	.012	4	view →
READ	Female	All	−1.225	.007	2	view →
KICH	Male	All	+0.729	.006	2	view →
STAD	All	All	+0.667	.007	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

B2M–KIRC

Open the KIRC breakdown →