B2M

Across TCGA pan-cancer cohorts, B2M RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated B2M data layer compared with 4 for mutation status.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher B2M RNA is associated with better overall survival. In most high-consensus cancer types, elevated B2M expression acts as an unfavorable survival marker, although some lineages such as SKCM and KIRC show a favorable association.

SKCM, UVM, and KIRC are the cancer types where B2M RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	OS	Median	All	0.417	0.260	<.001	119	view →
UVM	OS	Median	All	0.417	0.759	<.001	106	view →
KIRC	DFS	Quartile	All	0.710	0.470	.001	82	view →
LGG	OS	Median	All	0.744	0.877	<.001	45	view →
HNSC	OS	Tertile	III,IV	0.668	0.807	.002	37	view →
PAAD	DFS	Tertile	All	0.220	0.563	.002	34	view →
THYM	DFS	Median	II,III,IV	0.808	0.969	.002	34	view →
LIHC	DFS	Median	III,IV	0.332	0.088	<.001	32	view →
LUSC	DFS	Tertile	II,III,IV	0.288	0.506	.001	30	view →
SARC	OS	Median	All	0.895	0.776	<.001	25	view →
READ	DFS	Median	II,III,IV	0.881	0.705	.003	21	view →
PRAD	DFS	Median	All	0.885	0.699	<.001	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

B2M–SKCM (OS)

Open the SKCM breakdown →