AURKC

Across TCGA cell cohorts, AURKC mutation is significantly associated with the mutation status of many other genes, with 3,068 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible AURKC-associated genes across cancer lineages are SLC2A1, OR52N4, and KCND2. Each is linked with AURKC in more than 2 cancer types. Because this analysis shows association rather than direction, both AURKC-to-partner and partner-to-AURKC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLC2A1 grouped by AURKC-low versus AURKC-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AURKC→partner) and Y-score (partner→AURKC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	SLC2A1 →	+5.824	+5.824	.002	.002	1	3
SKIN	OR52N4 →	+4.239	+5.053	.007	.007	1	3
LARGE_INTESTINE	KCND2 →	+2.630	+4.510	<.001	<.001	1	3
LARGE_INTESTINE	GLI2 →	+1.951	+3.015	.006	.006	1	3
SKIN	OR4F15 →	+4.239	+5.053	.007	.007	1	3
CNS	TNN →	+4.459	+5.277	.005	.005	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,068 associations by consensus.

SLC2A1 by AURKC expression — SKIN

Explore this box plot interactively →