AURKC

Across TCGA pan-cancer cohorts, AURKC RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of AURKC’s most consistent transcriptional readouts.

The strongest signal is observed in cholangiocarcinoma (CHOL), where AURKC RNA is more highly expressed in tumor relative to normal tissue. In most cancer types AURKC is over-expressed in tumor, although a few such as COAD and KICH show the opposite, repressed pattern.

CHOL, THCA, and COAD are the cancer types where AURKC tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in AURKC RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CHOL	All	All	+0.878	<.001	3	view →
THCA	All	All	+0.285	.015	3	view →
COAD	Male	All	−0.275	.006	3	view →
KICH	Male	All	−0.553	.003	2	view →
KIRC	All	All	+0.124	.043	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

AURKC–CHOL

Open the CHOL breakdown →