AURKC

Across TCGA pan-cancer cohorts, AURKC RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated AURKC data layer compared with 7 for mutation status.

The strongest signal is observed in uveal melanoma (UVM), where higher AURKC RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated AURKC expression acts as an unfavorable survival marker, although some lineages such as BLCA and LUAD show a favorable association.

UVM, KIRC, and ACC are the cancer types where AURKC RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Tertile	All	0.395	0.885	.002	74	view →
KIRC	DFS	Median	All	0.494	0.717	<.001	55	view →
ACC	OS	Quartile	All	0.564	0.945	<.001	54	view →
BLCA	OS	Tertile	All	0.742	0.601	.003	47	view →
LGG	DFS	Median	All	0.647	0.813	<.001	36	view →
MESO	OS	Tertile	All	0.337	0.804	.001	29	view →
LUAD	OS	Tertile	III,IV	0.816	0.557	.001	27	view →
SKCM	OS	Tertile	All	0.423	0.260	<.001	26	view →
PRAD	DFS	Median	All	0.711	0.832	<.001	18	view →
READ	OS	Median	III,IV	0.817	0.962	.014	16	view →
GBM	OS	Tertile	All	0.521	0.215	.001	12	view →
PAAD	DFS	Quartile	All	0.495	0.142	.008	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

AURKC–UVM (DFS)

Open the UVM breakdown →