ATXN7L3

Across TCGA patient cohorts, ATXN7L3 mutation is significantly associated with the RNA expression of many other genes, with 6,106 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ATXN7L3-associated genes across cancer lineages are MIR6803, RN7SL248P, and RNA5SP411. Each is linked with ATXN7L3 in more than 1 cancer types. Because this analysis shows association rather than direction, both ATXN7L3-to-partner and partner-to-ATXN7L3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR6803 grouped by ATXN7L3-low versus ATXN7L3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATXN7L3→partner) and Y-score (partner→ATXN7L3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIR6803 →	+0.105	+3.893	<.001	.006	3	2
UCEC	RN7SL248P →	+0.058	+2.783	<.001	.009	3	2
UCEC	RNA5SP411 →	+0.868	+1.715	<.001	.003	3	2
HNSC	RNU6-17P →	+0.404	+6.608	<.001	.001	3	2
HNSC	RPS27P1 →	+0.209	+5.736	<.001	.003	3	2
HNSC	OR2P1P →	+0.062	+5.655	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,106 associations by consensus.

MIR6803 by ATXN7L3 expression — UCEC

Explore this box plot interactively →