ATXN7L3

Across TCGA pan-cancer cohorts, ATXN7L3 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated ATXN7L3 data layer compared with 7 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher ATXN7L3 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated ATXN7L3 expression acts as an unfavorable survival marker, although some lineages such as BRCA and ESCA show a favorable association.

ACC, LIHC, and KIRP are the cancer types where ATXN7L3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.331	0.789	<.001	99	view →
LIHC	OS	Median	All	0.699	0.855	<.001	86	view →
KIRP	DFS	Quartile	II,III,IV	0.098	1.000	.001	79	view →
UVM	DFS	Tertile	II,III,IV	0.453	0.807	<.001	57	view →
CESC	DFS	Quartile	All	0.760	0.903	.001	46	view →
BRCA	OS	Median	III,IV	0.946	0.853	<.001	39	view →
PAAD	OS	Tertile	All	0.459	0.737	.002	28	view →
BLCA	DFS	Tertile	IV	0.240	0.584	.010	24	view →
KIRC	DFS	Quartile	III,IV	0.596	0.849	.013	24	view →
ESCA	DFS	Tertile	II,III,IV	1.000	0.292	.024	24	view →
MESO	OS	Quartile	All	0.431	0.660	.015	14	view →
THYM	OS	Median	All	0.960	0.768	.008	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

ATXN7L3–ACC (DFS)

Open the ACC breakdown →