ATF7-NPFF

Across TCGA patient cohorts, ATF7-NPFF mutation is significantly associated with the RNA expression of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ATF7-NPFF-associated genes across cancer lineages are MIRLET7A1, RNU6-1082P, and SLCO1B7. Each is linked with ATF7-NPFF in more than 1 cancer types. Because this analysis shows association rather than direction, both ATF7-NPFF-to-partner and partner-to-ATF7-NPFF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIRLET7A1 grouped by ATF7-NPFF-low versus ATF7-NPFF-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATF7-NPFF→partner) and Y-score (partner→ATF7-NPFF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIRLET7A1 →	+0.681	+4.130	.007	.004	3	1
UCEC	RNU6-1082P →	+0.552	+5.136	<.001	<.001	3	1
UCEC	SLCO1B7 →	+0.221	+3.927	<.001	.007	3	1
UCEC	RNU6-19P →	+0.465	+3.969	<.001	.005	3	1
UCEC	RNU6ATAC3P →	+0.438	+3.809	.001	.007	3	1
UCEC	RNU4-53P →	+0.757	+3.800	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

MIRLET7A1 by ATF7-NPFF expression — UCEC

Explore this box plot interactively →