ATF7-NPFF

Across TCGA pan-cancer cohorts, ATF7-NPFF RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated ATF7-NPFF data layer compared with 1 for mutation status.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher ATF7-NPFF RNA is associated with worse overall survival. In most high-consensus cancer types, elevated ATF7-NPFF expression acts as an unfavorable survival marker, although some lineages such as HNSC and PAAD show a favorable association.

ACC, KIRC, and HNSC are the cancer types where ATF7-NPFF RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	OS	Tertile	All	0.611	0.947	<.001	127	view →
KIRC	DFS	Median	All	0.462	0.706	<.001	117	view →
HNSC	OS	Tertile	II,III,IV	0.542	0.328	<.001	104	view →
PAAD	OS	Quartile	All	0.531	0.203	<.001	53	view →
LIHC	DFS	Median	All	0.211	0.382	.004	28	view →
UVM	DFS	Tertile	III,IV	0.253	0.774	.009	25	view →
LGG	DFS	Median	All	0.674	0.796	<.001	24	view →
BLCA	DFS	Tertile	II,III,IV	0.601	0.435	.003	24	view →
PRAD	DFS	Median	All	0.822	0.937	<.001	22	view →
COAD	OS	Quartile	All	0.809	0.916	.002	17	view →
SKCM	OS	Tertile	IV	1.000	0.211	.013	15	view →
LUAD	DFS	Median	IV	0.326	0.766	.017	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

ATF7-NPFF–ACC (OS)

Open the ACC breakdown →