ATF7-NPFF

Across TCGA pan-cancer cohorts, ATF7-NPFF RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of ATF7-NPFF’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where ATF7-NPFF RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ATF7-NPFF is over-expressed in tumor, although a few such as LUAD and BRCA show the opposite, repressed pattern.

KIRC, LIHC, and LUAD are the cancer types where ATF7-NPFF tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ATF7-NPFF RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	All	+0.408	<.001	10	view →
LIHC	All	II,III,IV	+0.438	<.001	8	view →
LUAD	Male	All	−0.663	<.001	7	view →
BRCA	Female	All	−0.837	<.001	6	view →
LUSC	All	All	−0.445	<.001	5	view →
CHOL	Male	All	+1.765	<.001	3	view →
KIRP	All	IV	+0.645	.010	2	view →
THCA	All	All	−0.198	.005	2	view →
KICH	Male	IV	+0.260	.028	1	view →
COAD	All	All	+0.193	.046	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

ATF7-NPFF–KIRC

Open the KIRC breakdown →