RNA, U4 small nuclear 53, pseudogeneGenealiases: []
Q-omics provides the consensus-scored RNU4-53P profile across patient tissues and cancer cell-line models. RNU4-53P expression is associated with patient survival in 14 of 34 cancer types, with the highest sampling consensus in UVM. Among the 18 cancer types available for tumor–normal comparison, RNU4-53P is differentially expressed in 6, with the highest sampling consensus in LUSC. Additionally, RNU4-53P RNA expression shows 12,074 significant gene co-expression associations, with the highest sampling consensus in UVM. Together, these results highlight UVM, and LUSC as cancer lineages where RNU4-53P shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for RNU4-53P — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes RNU4-53P survival associations across molecular data types. RNU4-53P RNA expression shows survival associations in the most cancer types (14). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible RNU4-53P RNA expression–survival associations across cancer types. High RNU4-53P expression shows unfavorable associations in UVM, LUAD, TGCT, HNSC, LIHC and ACC. The UVM Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify UVM as the clearest survival context for RNU4-53P RNA expression.
This table summarizes RNU4-53P tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 6. The strongest signals are observed in LUSC for RNA.
This table ranks reproducible tumor–normal expression differences for RNU4-53P. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. RNU4-53P shows lower tumor expression in KIRP and higher tumor expression in LUSC, HNSC, BLCA, LUAD and CHOL. The LUSC box plot shows higher RNU4-53P RNA expression in tumor versus normal tissue (log2 FC = +0.260, t-test p = .001).
This table shows molecular features associated with RNU4-53P in patient tissues and cancer cell lines. In patient samples, RNU4-53P shows the broadest associations at the RNA and protein expression levels, with UVM recurring as the lineage with the largest associated feature set.
