ARVCF

Across TCGA cell cohorts, ARVCF mutation is significantly associated with the mutation status of many other genes, with 3,426 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ARVCF-associated genes across cancer lineages are PKN1, DOCK11, and MYO3A. Each is linked with ARVCF in more than 4 cancer types. Because this analysis shows association rather than direction, both ARVCF-to-partner and partner-to-ARVCF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PKN1 grouped by ARVCF-low versus ARVCF-high in UPPER_AERODIGESTIVE_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARVCF→partner) and Y-score (partner→ARVCF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	PKN1 →	+5.392	+5.392	.004	.004	1	5
UPPER_AERODIGESTIVE_TRACT	DOCK11 →	+4.392	+4.954	.008	.008	1	5
LARGE_INTESTINE	MYO3A →	+1.693	+2.287	.005	.005	1	5
KIDNEY	COL4A5 →	+5.000	+5.000	.006	.006	1	4
BLOOD_Lymphoma	FAM171B →	+3.316	+3.316	.006	.006	1	4
LUNG_NSCLC_LUAD	DAPK1 →	+4.772	+5.339	.004	.004	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,426 associations by consensus.

PKN1 by ARVCF expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →