ARVCF

Across TCGA pan-cancer cohorts, ARVCF RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of ARVCF’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where ARVCF RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ARVCF is over-expressed in tumor, although a few such as THCA and BRCA show the opposite, repressed pattern.

COAD, HNSC, and THCA are the cancer types where ARVCF tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ARVCF RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	IV	+1.254	<.001	11	view →
HNSC	Male	III,IV	+1.116	<.001	8	view →
THCA	All	All	−0.304	.001	8	view →
UCEC	All	II,III,IV	+1.321	<.001	6	view →
BLCA	All	All	+0.611	.047	4	view →
BRCA	Female	All	−0.391	.002	4	view →
KIRP	All	III,IV	−0.614	.009	3	view →
CHOL	All	All	+1.157	<.001	2	view →
KICH	All	All	−0.743	.002	2	view →
READ	All	All	+0.651	.007	2	view →
PRAD	All	All	+0.530	<.001	2	view →
LUAD	All	All	−0.305	.026	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

ARVCF–COAD

Open the COAD breakdown →