ARHGEF40

Across TCGA cell cohorts, ARHGEF40 mutation is significantly associated with the RNA expression of many other genes, with 604 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ARHGEF40-associated genes across cancer lineages are OR1L3, SGCB, and MS4A7. Each is linked with ARHGEF40 in more than 1 cancer types. Because this analysis shows association rather than direction, both ARHGEF40-to-partner and partner-to-ARHGEF40 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR1L3 grouped by ARHGEF40-low versus ARHGEF40-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARHGEF40→partner) and Y-score (partner→ARHGEF40) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	OR1L3 →	+0.014	+4.415	.001	.007	3	2
LARGE_INTESTINE	SGCB →	+0.872	+2.628	.003	.002	3	2
LARGE_INTESTINE	MS4A7 →	+0.028	+2.164	.001	.007	3	2
LUNG_NSCLC_LUSC	PIGY →	+1.158	+4.108	.008	.005	3	1
BLOOD_Lymphoma	BANF2 →	+0.071	+4.643	<.001	.005	3	1
BLOOD_Leukemia	SLC32A1 →	+0.450	+3.223	.002	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 604 associations by consensus.

OR1L3 by ARHGEF40 expression — SKIN

Explore this box plot interactively →