ARHGEF40

Across TCGA pan-cancer cohorts, ARHGEF40 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of ARHGEF40’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where ARHGEF40 RNA is repressed in tumor relative to normal tissue. In most cancer types ARHGEF40 is over-expressed in tumor, although a few such as LUAD and THCA show the opposite, repressed pattern.

LUAD, THCA, and HNSC are the cancer types where ARHGEF40 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ARHGEF40 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Female	All	−0.605	<.001	8	view →
THCA	Male	III,IV	−1.134	.010	7	view →
HNSC	All	III,IV	+0.966	.001	7	view →
KICH	All	All	−0.832	<.001	7	view →
LUSC	All	II,III,IV	−0.641	<.001	7	view →
LIHC	Female	II,III,IV	+1.290	<.001	6	view →
BRCA	All	All	−1.262	<.001	6	view →
KIRP	Male	II,III,IV	+0.549	.005	6	view →
STAD	Male	II,III,IV	+0.992	.001	5	view →
CHOL	Female	All	+1.596	.007	2	view →
PRAD	All	All	−0.995	<.001	2	view →
UCEC	All	All	−0.987	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

ARHGEF40–LUAD

Open the LUAD breakdown →