ARHGEF40

Across TCGA pan-cancer cohorts, ARHGEF40 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated ARHGEF40 data layer compared with 12 for mutation status and 3 for mass-spec protein.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where higher ARHGEF40 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated ARHGEF40 expression acts as an unfavorable survival marker, although some lineages such as KIRC and KIRP show a favorable association.

LUSC, KIRC, and ACC are the cancer types where ARHGEF40 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUSC	DFS	Quartile	III,IV	0.107	0.935	.001	72	view →
KIRC	OS	Tertile	All	0.737	0.509	<.001	50	view →
ACC	DFS	Median	All	0.402	0.756	<.001	49	view →
UVM	OS	Median	III,IV	0.246	0.836	.003	34	view →
HNSC	OS	Quartile	III,IV	0.538	0.874	.003	27	view →
LIHC	DFS	Median	All	0.474	0.611	.001	26	view →
LUAD	DFS	Quartile	II,III,IV	0.455	0.734	.006	17	view →
MESO	OS	Median	II,III,IV	0.461	0.662	.004	15	view →
KIRP	OS	Median	III,IV	0.906	0.686	.014	12	view →
BRCA	OS	Quartile	III,IV	0.795	0.600	.007	10	view →
CHOL	DFS	Median	III,IV	0.127	0.647	.006	9	view →
CESC	DFS	Median	All	0.772	0.872	.004	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

ARHGEF40–LUSC (DFS)

Open the LUSC breakdown →