ARHGEF25

Across TCGA patient cohorts, ARHGEF25 protein abundance is significantly associated with the RNA expression of many other genes, with 5,181 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible ARHGEF25-associated genes across cancer lineages are CHRDL1, LMOD1, and MEOX2. Each is linked with ARHGEF25 in more than 5 cancer types. Because this analysis shows association rather than direction, both ARHGEF25-to-partner and partner-to-ARHGEF25 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ARHGEF25 versus CHRDL1 in BRCA, with a Pearson correlation of 0.54.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARHGEF25→partner) and Y-score (partner→ARHGEF25) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CHRDL1 →	+3.038	+0.984	<.001	.002	3	6
COAD	LMOD1 →	+1.800	+0.498	<.001	.004	3	5
BRCA	MEOX2 →	+1.883	+0.817	<.001	<.001	3	5
BRCA	ADH1B →	+3.491	+0.864	<.001	.001	3	5
OV	GYPC →	+1.009	+1.164	.001	.005	2	5
BRCA	SFRP1 →	+2.565	+0.761	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,181 associations by consensus.

ARHGEF25 vs CHRDL1 — BRCA

Explore this scatter interactively →