ARHGEF25

Across TCGA pan-cancer cohorts, ARHGEF25 RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated ARHGEF25 data layer compared with 5 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher ARHGEF25 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated ARHGEF25 expression acts as an unfavorable survival marker, although some lineages such as UCS and LUAD show a favorable association.

ACC, UVM, and KIRC are the cancer types where ARHGEF25 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.192	0.674	<.001	126	view →
UVM	DFS	Median	II,III,IV	0.579	0.870	<.001	105	view →
KIRC	DFS	Quartile	II,III,IV	0.397	0.656	<.001	92	view →
BLCA	OS	Tertile	All	0.341	0.595	.001	56	view →
COAD	DFS	Median	All	0.627	0.744	.004	36	view →
THCA	OS	Tertile	III,IV	0.845	1.000	.017	25	view →
UCS	DFS	Quartile	III,IV	0.533	0.085	.008	24	view →
CESC	DFS	Median	All	0.426	0.635	.002	18	view →
LUAD	OS	Quartile	II,III,IV	0.850	0.569	.001	14	view →
CHOL	DFS	Tertile	All	0.528	0.154	.033	12	view →
SCLC	DFS	Median	IV	0.137	0.559	.008	12	view →
LGG	DFS	Quartile	All	0.650	0.420	.017	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

ARHGEF25–ACC (DFS)

Open the ACC breakdown →