ARG1

Across TCGA cell cohorts, ARG1 mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible ARG1-associated genes across cancer lineages are OR4N2, AVPR1B, and TMEM114. Each is linked with ARG1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ARG1-to-partner and partner-to-ARG1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR4N2 grouped by ARG1-low versus ARG1-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARG1→partner) and Y-score (partner→ARG1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	OR4N2 →	+0.164	+4.977	<.001	.007	3	1
SKIN	AVPR1B →	+0.013	+5.415	<.001	.004	3	1
SKIN	TMEM114 →	+0.051	+4.977	<.001	.007	3	1
LARGE_INTESTINE	XKR3 →	+0.076	+3.793	<.001	.007	3	1
LARGE_INTESTINE	PROP1 →	+0.023	+4.054	<.001	.004	3	1
LARGE_INTESTINE	OR2AJ1 →	+0.015	+3.684	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

OR4N2 by ARG1 expression — SKIN

Explore this box plot interactively →