ARG1

Across TCGA pan-cancer cohorts, ARG1 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of ARG1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where ARG1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ARG1 is over-expressed in tumor, although a few such as THCA and LIHC show the opposite, repressed pattern.

KIRC, THCA, and LIHC are the cancer types where ARG1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ARG1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	All	All	+0.102	<.001	9	view →
THCA	Male	III,IV	−0.298	<.001	8	view →
LIHC	All	II,III,IV	−2.017	<.001	7	view →
BRCA	All	III,IV	−0.345	<.001	6	view →
UCEC	All	All	−0.282	.004	6	view →
CHOL	Female	All	−8.593	<.001	5	view →
LUAD	Female	II,III,IV	−0.566	<.001	5	view →
LUSC	All	All	−0.472	<.001	5	view →
KICH	All	All	−0.152	.004	4	view →
COAD	All	All	−0.110	.014	3	view →
HNSC	All	All	−0.679	.033	2	view →
STAD	Male	All	−0.410	.040	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

ARG1–KIRC

Open the KIRC breakdown →