Across TCGA patient cohorts, AQP12A mutation is significantly associated with the RNA expression of many other genes, with 362 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AQP12A-associated genes across cancer lineages are LINC00251, OR10R3P, and LINC02448. Each is linked with AQP12A in more than 1 cancer types. Because this analysis shows association rather than direction, both AQP12A-to-partner and partner-to-AQP12A results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AQP12A→partner) and Y-score (partner→AQP12A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	LINC00251 →	+0.078	+4.883	<.001	.006	3	2
LGG	OR10R3P →	+0.064	+7.977	<.001	.007	3	2
BRCA	LINC02448 →	+0.188	+5.064	.001	.004	3	2
LUAD	RNA5SP377 →	+0.463	+5.888	<.001	.002	3	2
LUAD	KRTAP4-16 →	+0.097	+5.798	<.001	.003	3	2
UCEC	RNU4-13P →	+0.136	+3.879	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 362 associations by consensus.

Exploration

AQP12A survival (RNA) · tumor vs normal (RNA) · all AQP12A data types