Across TCGA pan-cancer cohorts, AQP12A RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of AQP12A’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where AQP12A RNA is repressed in tumor relative to normal tissue. In most cancer types AQP12A is over-expressed in tumor, although a few such as COAD and READ show the opposite, repressed pattern.

COAD, READ, and THCA are the cancer types where AQP12A tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in AQP12A RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	II,III,IV	−0.466	<.001	11	view →
READ	Male	All	−0.463	.007	4	view →
THCA	All	All	−0.029	<.001	4	view →
BRCA	All	All	+0.009	.002	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: AQP12A RNA expression & survival · all AQP12A data types