AQP11

Across TCGA patient cohorts, AQP11 mutation is significantly associated with the RNA expression of many other genes, with 83 significant associations in total. BLCA shows the largest number of these associations.

The most reproducible AQP11-associated genes across cancer lineages are RNU6-794P, OR5A2, and RN7SKP25. Each is linked with AQP11 in more than 1 cancer types. Because this analysis shows association rather than direction, both AQP11-to-partner and partner-to-AQP11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-794P grouped by AQP11-low versus AQP11-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AQP11→partner) and Y-score (partner→AQP11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	RNU6-794P →	+0.264	+4.814	<.001	.003	3	2
BLCA	OR5A2 →	+0.082	+5.040	<.001	.002	3	2
BLCA	RN7SKP25 →	+0.194	+3.623	.002	.004	3	2
LUSC	MIR4304 →	+0.574	+4.548	<.001	.009	3	2
SKCM	RN7SL423P →	+0.124	+7.816	<.001	.008	3	1
BLCA	IGLCOR22-1 →	+0.370	+3.266	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 83 associations by consensus.

RNU6-794P by AQP11 expression — BLCA

Explore this box plot interactively →