AQP11

Across TCGA pan-cancer cohorts, AQP11 RNA is linked to patient survival in 28 of 34 cancer types, making it the most broadly survival-associated AQP11 data layer compared with 4 for mutation status.

The strongest signal is observed in breast invasive carcinoma (BRCA), where higher AQP11 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated AQP11 expression acts as an unfavorable survival marker, although some lineages such as BRCA and OV show a favorable association.

BRCA, KICH, and OV are the cancer types where AQP11 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BRCA	DFS	Median	III,IV	0.945	0.809	<.001	77	view →
KICH	OS	Median	III,IV	0.340	1.000	.001	71	view →
OV	OS	Tertile	II,III,IV	0.369	0.269	.007	50	view →
UCEC	DFS	Quartile	All	0.543	0.817	<.001	38	view →
LAML	DFS	Median	All	0.468	0.291	.024	20	view →
STAD	DFS	Tertile	All	0.613	0.438	.005	19	view →
LGG	DFS	Quartile	All	0.579	0.345	.005	15	view →
MESO	DFS	Tertile	All	0.168	0.280	.025	15	view →
CESC	DFS	Quartile	All	0.634	0.811	.010	14	view →
SARC	OS	Quartile	All	0.569	0.871	.002	14	view →
KIRP	DFS	Tertile	All	0.861	0.952	.005	12	view →
UVM	OS	Tertile	III,IV	0.461	0.931	.008	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 28 lineages.

AQP11–BRCA (DFS)

Open the BRCA breakdown →