AQP11

Across TCGA pan-cancer cohorts, AQP11 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of AQP11’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where AQP11 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types AQP11 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

LUAD, THCA, and HNSC are the cancer types where AQP11 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in AQP11 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Male	II,III,IV	+1.206	<.001	11	view →
THCA	Male	All	−0.684	<.001	10	view →
HNSC	All	III,IV	+0.505	<.001	10	view →
LUSC	Male	II,III,IV	+0.914	<.001	8	view →
KICH	All	II,III,IV	−1.096	<.001	7	view →
READ	All	All	−0.816	<.001	7	view →
CHOL	Male	All	−1.768	<.001	5	view →
COAD	Female	II,III,IV	−1.061	<.001	5	view →
BLCA	All	All	+0.587	.009	4	view →
PRAD	All	All	+0.554	.014	2	view →
LIHC	Male	All	+0.570	.003	1	view →
KIRC	All	All	−0.253	.047	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

AQP11–LUAD

Open the LUAD breakdown →