Across TCGA patient cohorts, APOC4-APOC2 mutation is significantly associated with the RNA expression of many other genes, with 13 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible APOC4-APOC2-associated genes across cancer lineages are CASKP1, NMBR-AS1, and LINC01661. Each is linked with APOC4-APOC2 in more than 1 cancer types. Because this analysis shows association rather than direction, both APOC4-APOC2-to-partner and partner-to-APOC4-APOC2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (APOC4-APOC2→partner) and Y-score (partner→APOC4-APOC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	CASKP1 →	+0.072	+5.224	.001	.007	3	1
SKCM	NMBR-AS1 →	+0.236	+5.513	<.001	.004	3	1
SKCM	LINC01661 →	+0.094	+5.097	<.001	.008	3	1
SKCM	RNU6-1169P →	+0.365	+5.362	<.001	.005	3	1
SKCM	RNU6-522P →	+0.392	+5.970	<.001	.002	3	1
SKCM	MYCLP1 →	+0.045	+4.979	.007	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

Exploration

APOC4-APOC2 survival (RNA) · tumor vs normal (RNA) · all APOC4-APOC2 data types