Across TCGA cell cohorts, APOC4-APOC2 mutation is significantly associated with the mutation status of many other genes, with 180 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible APOC4-APOC2-associated genes across cancer lineages are CD96, TRAPPC8, and CCDC174. Each is linked with APOC4-APOC2 in more than 1 cancer types. Because this analysis shows association rather than direction, both APOC4-APOC2-to-partner and partner-to-APOC4-APOC2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (APOC4-APOC2→partner) and Y-score (partner→APOC4-APOC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	CD96 →	+5.321	+5.894	.002	.002	1	1
BLOOD_Leukemia	TRAPPC8 →	+4.000	+5.050	.008	.008	1	1
BLOOD_Leukemia	CCDC174 →	+5.321	+5.894	.002	.002	1	1
BLOOD_Leukemia	BRPF1 →	+4.321	+5.285	.005	.005	1	1
BLOOD_Leukemia	ACTC1 →	+4.000	+5.050	.008	.008	1	1
BLOOD_Leukemia	TEPP →	+6.321	+6.321	.001	.001	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 180 associations by consensus.

Exploration

APOC4-APOC2 survival (RNA) · tumor vs normal (RNA) · all APOC4-APOC2 data types