AP4S1

Across TCGA patient cohorts, AP4S1 mutation is significantly associated with the RNA expression of many other genes, with 52 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible AP4S1-associated genes across cancer lineages are OR8B6P, RNU6-886P, and GSTA8P. Each is linked with AP4S1 in more than 1 cancer types. Because this analysis shows association rather than direction, both AP4S1-to-partner and partner-to-AP4S1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR8B6P grouped by AP4S1-low versus AP4S1-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AP4S1→partner) and Y-score (partner→AP4S1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	OR8B6P →	+0.078	+5.882	.002	.002	3	2
UCEC	RNU6-886P →	+0.518	+3.488	<.001	.008	3	2
SKCM	GSTA8P →	+0.100	+3.294	.007	.004	3	2
SKCM	LINC01661 →	+0.041	+3.682	.007	.004	3	1
SKCM	EEF1A1P31 →	+0.119	+4.006	<.001	.003	3	1
SKCM	CELF2-AS2 →	+0.040	+3.564	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 52 associations by consensus.

OR8B6P by AP4S1 expression — LUSC

Explore this box plot interactively →