AP4S1

Across TCGA pan-cancer cohorts, AP4S1 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of AP4S1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where AP4S1 RNA is repressed in tumor relative to normal tissue. In most cancer types AP4S1 is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

KICH, THCA, and HNSC are the cancer types where AP4S1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in AP4S1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Male	IV	−1.443	<.001	10	view →
THCA	Male	III,IV	−1.021	<.001	10	view →
HNSC	All	III,IV	+0.544	<.001	9	view →
KIRC	Male	II,III,IV	−0.423	<.001	6	view →
LUSC	Male	III,IV	−0.632	.001	5	view →
CHOL	Male	All	+0.925	<.001	4	view →
BLCA	Male	All	−0.490	.005	4	view →
BRCA	Female	All	−0.298	<.001	4	view →
COAD	All	All	−0.269	.013	4	view →
KIRP	Male	All	−0.371	.002	3	view →
UCEC	All	All	−0.844	<.001	2	view →
READ	All	All	−0.700	.015	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

AP4S1–KICH

Open the KICH breakdown →