AP1M1

Across TCGA cell cohorts, AP1M1 mutation is significantly associated with the mutation status of many other genes, with 4,979 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible AP1M1-associated genes across cancer lineages are TET3, SASH1, and KNG1. Each is linked with AP1M1 in more than 3 cancer types. Because this analysis shows association rather than direction, both AP1M1-to-partner and partner-to-AP1M1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TET3 grouped by AP1M1-low versus AP1M1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AP1M1→partner) and Y-score (partner→AP1M1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TET3 →	+2.099	+4.064	.001	.001	1	4
BREAST	SASH1 →	+5.442	+5.442	<.001	<.001	1	3
BREAST	KNG1 →	+4.857	+4.297	.009	.009	1	3
BREAST	SEMA6C →	+2.857	+4.142	.008	.008	1	3
BREAST	SIN3A →	+4.857	+4.297	.009	.009	1	3
BREAST	SEMA4B →	+4.857	+4.297	.009	.009	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,979 associations by consensus.

TET3 by AP1M1 expression — LARGE_INTESTINE

Explore this box plot interactively →