AMT

Across TCGA cell cohorts, AMT mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible AMT-associated genes across cancer lineages are ACER1, LRRC3C, and TBC1D3. Each is linked with AMT in more than 1 cancer types. Because this analysis shows association rather than direction, both AMT-to-partner and partner-to-AMT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACER1 grouped by AMT-low versus AMT-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AMT→partner) and Y-score (partner→AMT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ACER1 →	+0.083	+3.823	.007	.006	3	1
LARGE_INTESTINE	LRRC3C →	+0.395	+3.777	<.001	.007	3	1
LARGE_INTESTINE	TBC1D3 →	+0.112	+4.688	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

ACER1 by AMT expression — LARGE_INTESTINE

Explore this box plot interactively →