AMT

Across TCGA pan-cancer cohorts, AMT RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of AMT’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where AMT RNA is repressed in tumor relative to normal tissue. In most cancer types AMT is over-expressed in tumor, although a few such as KIRC and KIRP show the opposite, repressed pattern.

KIRC, KIRP, and COAD are the cancer types where AMT tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in AMT RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	IV	−1.475	<.001	11	view →
KIRP	Male	III,IV	−2.836	<.001	9	view →
COAD	Female	II,III,IV	−1.291	<.001	9	view →
KICH	Male	II,III,IV	−1.762	<.001	8	view →
LUSC	All	II,III,IV	−0.932	<.001	7	view →
LUAD	All	III,IV	−0.869	<.001	7	view →
BRCA	Female	All	−1.315	<.001	6	view →
UCEC	All	All	−0.966	.008	4	view →
STAD	All	All	−0.670	.002	4	view →
PRAD	All	All	−1.130	<.001	2	view →
CHOL	All	All	−1.005	.003	2	view →
BLCA	All	All	−0.754	.028	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

AMT–KIRC

Open the KIRC breakdown →