AMT

Across TCGA pan-cancer cohorts, AMT RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated AMT data layer compared with 5 for mutation status and 8 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher AMT RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated AMT expression acts as an unfavorable survival marker, although some lineages such as KIRP and BLCA show a favorable association.

KIRP, BLCA, and LUAD are the cancer types where AMT RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	DFS	Median	All	0.969	0.849	<.001	103	view →
BLCA	DFS	Quartile	All	0.757	0.543	.001	59	view →
LUAD	OS	Tertile	All	0.862	0.753	<.001	52	view →
READ	OS	Quartile	All	1.000	0.820	<.001	50	view →
LGG	DFS	Median	All	0.786	0.873	<.001	38	view →
SKCM	DFS	Quartile	II,III,IV	0.472	0.212	<.001	31	view →
HNSC	OS	Median	III,IV	0.730	0.583	.003	22	view →
THYM	DFS	Tertile	III,IV	1.000	0.459	.021	15	view →
STAD	OS	Median	IV	0.642	0.203	.006	15	view →
UCS	DFS	Median	III,IV	0.559	0.283	.020	14	view →
UVM	DFS	Median	All	0.368	0.694	.007	8	view →
KICH	DFS	Tertile	II,III,IV	0.467	0.926	.008	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

AMT–KIRP (DFS)

Open the KIRP breakdown →