ALX1

Across TCGA patient cohorts, ALX1 mutation is significantly associated with the RNA expression of many other genes, with 955 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ALX1-associated genes across cancer lineages are RNU6-663P, RAB28P3, and SNX18P23. Each is linked with ALX1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ALX1-to-partner and partner-to-ALX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-663P grouped by ALX1-low versus ALX1-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ALX1→partner) and Y-score (partner→ALX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	RNU6-663P →	+0.417	+5.812	<.001	.003	3	2
UCEC	RAB28P3 →	+0.075	+2.360	<.001	.001	3	2
READ	SNX18P23 →	+0.057	+4.653	<.001	.007	3	2
BLCA	RNU6-777P →	+0.303	+4.329	<.001	.001	3	2
SKCM	RNU6-1313P →	+0.298	+7.816	<.001	.008	3	2
SKCM	PABPC1L2B-AS1 →	+0.039	+7.816	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 955 associations by consensus.

RNU6-663P by ALX1 expression — CESC

Explore this box plot interactively →