ALX1

Across TCGA pan-cancer cohorts, ALX1 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated ALX1 data layer compared with 8 for mutation status.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where higher ALX1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated ALX1 expression acts as an unfavorable survival marker, although some lineages such as BRCA and UCS show a favorable association.

LIHC, KIRP, and BRCA are the cancer types where ALX1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LIHC	OS	Tertile	III,IV	0.331	0.764	.002	72	view →
KIRP	OS	Median	All	0.549	0.825	.002	69	view →
BRCA	OS	Median	All	0.977	0.947	.001	64	view →
UCEC	DFS	Tertile	All	0.580	0.824	<.001	50	view →
UCS	DFS	Tertile	II,III,IV	0.514	0.162	.002	42	view →
CHOL	DFS	Tertile	II,III,IV	0.085	0.571	.002	25	view →
COAD	DFS	Quartile	II,III,IV	0.528	0.698	.009	16	view →
ACC	DFS	Quartile	All	0.342	0.616	.004	12	view →
LAML	DFS	Tertile	All	0.652	0.303	.025	12	view →
BLCA	DFS	Median	All	0.219	0.480	.027	11	view →
LUAD	OS	Quartile	All	0.533	0.683	.029	11	view →
SKCM	OS	Median	II,III,IV	0.661	0.794	.017	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

ALX1–LIHC (OS)

Open the LIHC breakdown →