AKAIN1

Across TCGA patient cohorts, AKAIN1 mutation is significantly associated with the RNA expression of many other genes, with 431 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AKAIN1-associated genes across cancer lineages are SLC25A18, TANGO2, and TM2D3. Each is linked with AKAIN1 in more than 1 cancer types. Because this analysis shows association rather than direction, both AKAIN1-to-partner and partner-to-AKAIN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLC25A18 grouped by AKAIN1-low versus AKAIN1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AKAIN1→partner) and Y-score (partner→AKAIN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SLC25A18 →	+0.416	+3.332	<.001	.005	3	1
UCEC	TANGO2 →	+0.500	+2.595	.001	.006	3	1
UCEC	TM2D3 →	+0.487	+2.595	.001	.006	3	1
UCEC	RPS27L →	+0.636	+2.606	.003	.006	3	1
UCEC	KRT5 →	-2.090	-3.700	.004	.001	3	1
UCEC	CIDECP1 →	+0.486	+2.638	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 431 associations by consensus.

SLC25A18 by AKAIN1 expression — UCEC

Explore this box plot interactively →