AKAIN1

Across TCGA pan-cancer cohorts, AKAIN1 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of AKAIN1’s most consistent transcriptional readouts.

The strongest signal is observed in breast invasive carcinoma (BRCA), where AKAIN1 RNA is repressed in tumor relative to normal tissue. In most cancer types AKAIN1 is over-expressed in tumor, although a few such as BRCA and KIRP show the opposite, repressed pattern.

BRCA, KIRP, and CHOL are the cancer types where AKAIN1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in AKAIN1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BRCA	All	All	−0.331	<.001	6	view →
KIRP	All	II,III,IV	−0.155	.006	4	view →
CHOL	All	All	−0.296	<.001	3	view →
STAD	All	III,IV	−0.276	.029	3	view →
KIRC	All	II,III,IV	−0.061	.019	3	view →
COAD	Female	IV	−0.270	.005	2	view →
BLCA	Male	IV	−0.220	.031	2	view →
KICH	Male	All	−0.158	.012	2	view →
LIHC	Female	II,III,IV	−0.219	.038	1	view →
THCA	Male	All	−0.080	.048	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

AKAIN1–BRCA

Open the BRCA breakdown →