AKAIN1

Across TCGA pan-cancer cohorts, AKAIN1 RNA is linked to patient survival in 17 of 34 cancer types, making it the most broadly survival-associated AKAIN1 data layer compared with 2 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher AKAIN1 RNA is associated with better overall survival. In most high-consensus cancer types, elevated AKAIN1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and SCLC show a favorable association.

HNSC, SCLC, and LGG are the cancer types where AKAIN1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	II,III,IV	0.879	0.637	<.001	99	view →
SCLC	DFS	Tertile	All	0.708	0.339	.001	45	view →
LGG	DFS	Median	All	0.499	0.305	<.001	45	view →
LUSC	DFS	Tertile	III,IV	0.243	0.667	<.001	36	view →
COAD	DFS	Median	III,IV	0.266	0.546	.001	35	view →
PAAD	DFS	Median	All	0.373	0.179	.001	32	view →
BLCA	OS	Tertile	All	0.819	0.543	.035	12	view →
LIHC	OS	Median	III,IV	0.768	0.469	.003	11	view →
SKCM	DFS	Quartile	III,IV	0.745	0.544	.012	9	view →
GBM	DFS	Median	All	0.263	0.166	.013	6	view →
ACC	DFS	Quartile	IV	0.582	0.096	.006	6	view →
DLBC	OS	Tertile	III,IV	0.707	1.000	.023	4	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 17 lineages.

AKAIN1–HNSC (OS)

Open the HNSC breakdown →