AHSG

Across TCGA cell cohorts, AHSG mutation is significantly associated with the RNA expression of many other genes, with 20 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible AHSG-associated genes across cancer lineages are FSCB, SLCO1C1, and FAM81B. Each is linked with AHSG in more than 1 cancer types. Because this analysis shows association rather than direction, both AHSG-to-partner and partner-to-AHSG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FSCB grouped by AHSG-low versus AHSG-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AHSG→partner) and Y-score (partner→AHSG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	FSCB →	+0.046	+4.906	<.001	.006	3	1
LARGE_INTESTINE	SLCO1C1 →	+0.479	+3.772	<.001	.003	3	1
LARGE_INTESTINE	FAM81B →	+0.285	+3.714	.002	.004	3	1
LARGE_INTESTINE	SPIC →	+0.207	+3.510	<.001	.003	3	1
LARGE_INTESTINE	CPLX4 →	+0.027	+4.807	<.001	<.001	3	1
LARGE_INTESTINE	CYP7A1 →	+0.032	+3.994	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

FSCB by AHSG expression — OESOPHAGUS

Explore this box plot interactively →