AHSG

Across TCGA pan-cancer cohorts, AHSG RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated AHSG data layer compared with 6 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher AHSG RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated AHSG expression acts as an unfavorable survival marker, although some lineages such as READ and LGG show a favorable association.

KIRP, LUAD, and READ are the cancer types where AHSG RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	DFS	Quartile	All	0.718	0.905	<.001	101	view →
LUAD	OS	Tertile	All	0.598	0.767	<.001	69	view →
READ	OS	Median	III,IV	0.682	0.290	<.001	50	view →
LGG	OS	Median	All	0.865	0.748	<.001	46	view →
CHOL	OS	Tertile	II,III,IV	0.272	0.934	.001	45	view →
DLBC	DFS	Median	III,IV	1.000	0.376	.008	35	view →
KICH	OS	Tertile	III,IV	0.125	0.815	<.001	34	view →
HNSC	DFS	Tertile	All	0.203	0.483	<.001	27	view →
LIHC	OS	Median	All	0.679	0.443	.001	22	view →
PCPG	OS	Tertile	All	0.736	0.982	.005	21	view →
BLCA	OS	Median	IV	0.299	0.738	<.001	18	view →
UVM	DFS	Median	All	0.289	0.626	.033	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

AHSG–KIRP (DFS)

Open the KIRP breakdown →