AHSG

Across TCGA pan-cancer cohorts, AHSG RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of AHSG’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where AHSG RNA is repressed in tumor relative to normal tissue. In most cancer types AHSG is over-expressed in tumor, although a few such as KICH and KIRC show the opposite, repressed pattern.

KICH, LUSC, and KIRC are the cancer types where AHSG tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in AHSG RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Male	All	−0.509	<.001	8	view →
LUSC	All	All	+0.489	<.001	6	view →
KIRC	Male	II,III,IV	−0.255	<.001	6	view →
LUAD	All	All	+0.166	<.001	6	view →
CHOL	Female	All	−10.783	<.001	5	view →
THCA	All	All	+0.085	<.001	5	view →
LIHC	All	All	−1.557	<.001	4	view →
COAD	All	All	+0.306	.012	4	view →
UCEC	All	III,IV	+0.166	.028	4	view →
HNSC	All	IV	+0.257	.021	3	view →
STAD	Male	III,IV	+0.203	.008	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

AHSG–KICH

Open the KICH breakdown →