AGO3

Across TCGA cell cohorts, AGO3 mutation is significantly associated with the RNA expression of many other genes, with 49 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible AGO3-associated genes across cancer lineages are TBC1D3, OR2F2, and OR13C7. Each is linked with AGO3 in more than 1 cancer types. Because this analysis shows association rather than direction, both AGO3-to-partner and partner-to-AGO3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TBC1D3 grouped by AGO3-low versus AGO3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AGO3→partner) and Y-score (partner→AGO3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TBC1D3 →	+0.057	+3.103	<.001	.004	3	2
LUNG_NSCLC_LUAD	OR2F2 →	+0.036	+6.266	<.001	<.001	3	1
LUNG_NSCLC_LUAD	OR13C7 →	+0.049	+6.266	<.001	<.001	3	1
BLOOD_Leukemia	CD207 →	+0.306	+4.523	<.001	.001	3	1
BLOOD_Leukemia	ACTRT1 →	+0.014	+4.786	.004	<.001	3	1
BLOOD_Leukemia	C20orf85 →	+0.018	+4.384	.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 49 associations by consensus.

TBC1D3 by AGO3 expression — LARGE_INTESTINE

Explore this box plot interactively →