AGO3

Across TCGA pan-cancer cohorts, AGO3 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated AGO3 data layer compared with 5 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher AGO3 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated AGO3 expression acts as an unfavorable survival marker, although some lineages such as HNSC and SCLC show a favorable association.

ACC, HNSC, and SCLC are the cancer types where AGO3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.354	0.788	<.001	111	view →
HNSC	DFS	Median	IV	0.396	0.251	<.001	49	view →
SCLC	DFS	Median	II,III,IV	0.710	0.386	.004	49	view →
LIHC	DFS	Tertile	All	0.420	0.577	.001	46	view →
CESC	DFS	Quartile	II,III,IV	0.454	0.857	.011	32	view →
UCS	OS	Quartile	III,IV	0.651	0.179	.007	26	view →
LGG	DFS	Median	All	0.679	0.801	.001	20	view →
MESO	OS	Median	III,IV	0.296	0.477	.004	19	view →
BLCA	DFS	Quartile	All	0.241	0.575	.005	19	view →
UCEC	DFS	Quartile	All	0.593	0.783	.001	18	view →
KIRP	DFS	Median	IV	0.038	0.527	.010	16	view →
LUAD	DFS	Quartile	III,IV	0.779	0.436	.022	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

AGO3–ACC (DFS)

Open the ACC breakdown →