AGAP11

Across TCGA patient cohorts, AGAP11 mutation is significantly associated with the RNA expression of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AGAP11-associated genes across cancer lineages are RN7SL565P, MIR208A, and HMX3. Each is linked with AGAP11 in more than 1 cancer types. Because this analysis shows association rather than direction, both AGAP11-to-partner and partner-to-AGAP11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL565P grouped by AGAP11-low versus AGAP11-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AGAP11→partner) and Y-score (partner→AGAP11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RN7SL565P →	+0.234	+7.816	<.001	.008	3	1
SKCM	MIR208A →	+0.607	+7.816	<.001	.008	3	1
UCEC	HMX3 →	+0.931	+3.859	.002	.004	3	1
UCEC	SPANXN3 →	+0.199	+3.638	<.001	.006	3	1
UCEC	RNU6-1169P →	+0.499	+3.717	<.001	.005	3	1
UCEC	FDX1P2 →	+0.256	+3.801	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

RN7SL565P by AGAP11 expression — SKCM

Explore this box plot interactively →